Rate of Sickling of Red Cells during Deoxygenation of Blood from Persons with Various Sickling Disorders
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چکیده
منابع مشابه
Rate of Sickling of Red Cells during Deoxygenation of Blood from Persons with Various Sickling Disorders.
By SAMUEL CIIARAcIIE AND C. LOCKARD CONLEY S ICKLED ERYTHROCYTES are rapidly removed for the circulation, an occurrence that accounts for the hemolytic aspects of sickle cell disease.’ Anemia is a usual result but is often asymptomatic and is not the principal cause of the high morbidity and reduced life span of affected persons. Many of the clinical manifestations of sicklemia have been attrib...
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Rapid transformatIon of discoid hemoglobin SS erythrocytes into grossly distorted sickled forms suggests alteration of surface/volume ratio. We, therefore, examined the effect of deoxygenation on red cell volume. ‘31llaholed albumin was used as a marker of plasma volume in normal (Hb AA), sickle (Hb SS), and sickle-C (Hb SC) blood. Heparinized blood was incubated for 30 mm at 37#{176}Cin a tpno...
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Sickling-induced cation fluxes contribute to cellular dehydration of sickle red blood cells (SS RBCs), which in turn potentiates sickling. This study examined the inhibition by dipyridamole of the sicklinginduced fluxes of Na1, K1, and Ca11 in vitro. At 2% hematocrit, 10 mM dipyridamole inhibited 65% of the increase in net fluxes of Na1 and K1 produced by deoxygenation of SS RBCs. Sickle-induce...
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Sickle cell disease affects approximately 5000 people in the UK predominantly of African and Afro-Caribbean origin.1 The majority of those affected live in inner city areas; for example it is the most common inherited condition in the City and Hackney district of London. There is a high morbidity and mortality in children with up to 10% dying within the first 10 years of life.2 Sickle cell rela...
متن کاملThe rate of sickling of cells containing sickle-cell haemoglobin.
1. A rapid-reaction apparatus was used to measure the rate at which cells containing sickle-cell haemoglobin (HbS) undergo morphological changes as a result of very rapid deoxygenation. The events occurring under these circumstances were found to take place in two stages. 2. The first consisted of a very rapid gelation of the cellular haemoglobin producing bizarre-shaped erythrocytes. The rate ...
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ژورنال
عنوان ژورنال: Blood
سال: 1964
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v24.1.25.25